Thromboprophylaxis Omission as a Risk Factor for Mortality
Kurt Mahan, MD, of Presbyterian Healthcare Services discusses the results of his large retrospective database study evaluating post-discharge thromboprophylaxis among acutely ill hospitalized patients. 12,000 patients were included for this study, and the risk factors for mortality were evaluated. Antiplatelet and anticoagulant therapy omission was identified as a risk factor for mortality. No clear duration of post-discharge prophylaxis was identified, however the Kaplan Meier curves for death in this study showed the curves separate strongly between 15-30 days and remained strongly divergent at 45 days. While there is no well-defined timeline for duration of optimal post-discharge prophylaxis, this 30-45 days noted in this study may be suggestive.