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FOLFOX Alone or Combined with Atezolizumab as Adjuvant Therapy in Stage III Colon Cancer (ATOMIC)
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Dr. Frank Sinicrope discusses FOLFOX Alone or Combined with Atezolizumab as Adjuvant Therapy in Stage III Colon Cancer with DNA Mismatch repair of MSI (ATOMIC) at ASCO 2017. For the ability to view on your mobile phone please visit us at MinuteCE.com

This transcript is software driven, please understand there may be errors.  Should any inaccuracies or omissions be found, please notify transcripts@MedEdOTG.com for correction.

Hi. I'm Dr. Frank Sinicrope from the Mayo Clinic in Rochester, Minnesota, and I'm here to discuss my poster of a trial in progress. This is a phase III trial of adjuvant chemotherapy with FOLFOX, with or without atezolizumab, an anti-PD-L1 antibody that is being studied in stage III colon cancer patients with deficient DNA mismatch repair or microsatellite instability.

This is a randomized phase III trial where patients will be randomized to standard FOLFOX chemotherapy for six months or they will receive FOLFOX with atezolizumab for six months, with continuation of the atezolizumab for an additional six months. The study population is of course patients with resected stage III colon cancer that have deficient DNA mismatch repair determined by immunohistochemistry.

This will be a 700-patient trial to be done through the Alliance for Clinical Trials in Oncology. We're very excited about this trial because we think that it has the potential to be practice-changing, whereby we can use immunotherapy to hopefully improve the survival of treated patients. This study builds upon the data for immune checkpoint inhibition in metastatic colon cancer with microsatellite instability where high levels of response and extended survival have been seen. I appreciate the interest in the poster, and I thank you for your attention.