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Hi, I'm Dr. Michael Gibson from Harvard Medical School. Today we're talking about a patient with VTE. This is a 67 year old female patient. She had a history of COPD. She was diagnosed with a severe respiratory infection. She was admitted to the hospital yesterday and was severely immobilized.
Now, she's expected to stay in the hospital for several days. So, here's the question, in general, what's the proximate risk of VTE developing during hospitalization? Is it 0%? .5%? 1.4% or 6.2%?
When the answer is shown here, the risk is 1.4% or answer C. Acutely ill hospitalized patients are at an increased risk of VTE during the hospitalization period. As we'll see in other segments, that risk extends beyond hospitalization at well.
So, the next question is this: How can the risk of VTE be reduced in this patient? The answer is this: Administering a 160 milligram loading dose of betrixaban followed by a maintenance dose of 80 milligrams for the next 35 to 42 days has recently been shown in the APEX study to reduce the risk of VTE compared to enoxaparin for the standard duration of hospitalization.
So to summarize, this was a patient who had COPD and an infection who was immobilized. The numbers indicate that these patients are at a high risk of VTE. This risk of VTE can be reduced by a new drug, betrixaban, given orally for the next 35 to 42 days as compared to the enoxaparin.
I hope you've enjoyed this segment.